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Olivia Goethals Selected Research

Dengue (Dengue Fever)

3/2024Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.
1/2024Multiplexed multicolor antiviral assay amenable for high-throughput research.
12/2023Modelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics.
1/2023Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors.
1/2023A pan-serotype antiviral to prevent and treat dengue: A journey from discovery to clinical development driven by public-private partnerships.
1/2023Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
12/2022From Oxetane to Thietane: Extending the Antiviral Spectrum of 2'-Spirocyclic Uridines by Substituting Oxygen with Sulfur.
1/2019Phylogenetically based establishment of a dengue virus panel, representing all available genotypes, as a tool in dengue drug discovery.
11/2017Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library.

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Olivia Goethals Research Topics

Disease

9Dengue (Dengue Fever)
03/2024 - 11/2017
5Infections
03/2024 - 10/2021
3Virus Diseases (Viral Diseases)
01/2024 - 12/2022
2HIV Infections (HIV Infection)
08/2011 - 11/2008
1Japanese Encephalitis
01/2024

Drug/Important Bio-Agent (IBA)

8Antiviral Agents (Antivirals)IBA
03/2024 - 11/2017
3JNJ-1802IBA
03/2024 - 01/2023
1Immune Sera (Antisera)IBA
01/2024
1Viral RNAIBA
12/2023
1NucleosidesIBA
12/2022
1(+)- 4- (3- ((1- (4- chlorophenyl)- 2- oxo2- (6- (trifluoromethoxy)indolin- 1- yl)ethyl)amino)- 5- methoxyphenoxy)butanoic acidIBA
10/2021
1NITD008IBA
01/2019
1EnzymesIBA
01/2019
1Raltegravir PotassiumFDA Link
08/2011
1IntegrasesIBA
08/2011
1Integrase InhibitorsIBA
11/2008

Therapy/Procedure

1Therapeutics
01/2023
1Highly Active Antiretroviral Therapy (HAART)
08/2011